Personnel

Director of Research at Inserm, for over 10 years now my research has aimed at understanding the mechanisms involved in a rare genetic disease called oculopharyngeal muscular dystrophy (OPMD). This disease affects the skeletal muscles with a late and very specific involvement of the muscles of the pharynx and of the eyelid. I have been trying to find therapeutic solutions for patients with this disease by developing gene, cell and pharmacological approaches. But our team is not only interested in the OPMD. We are also studying how human muscle regenerates, how it ages and how muscular fibrosis is established in many pathologies. In these different areas (aging, regeneration and pathology) we are more specifically interested in inter-cellular communication and in particular in the secretome of muscle cells and its consequences on the muscle environment.