TROLLET/MOULY Lab

Cellular and molecular orchestration in muscle regeneration, during ageing and in pathologies.

The team focuses on molecular and cellular actors involved in human in skeletal muscle regeneration, during ageing and in muscle dystrophies, particularly oculo-pharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). Our approaches aim at better understandng RNA metabolism, muscle regeneration, muscle stem cells and fibrosis, in order to develop therapeutic strategies.The team has developed a solid expertise on cellular models (incuding through the MyoLine platform for immortalization taht we have set up) and on xenotransplantation using several immunodeficient mouse models and different types of grafts.

Research projects currently developed in parralel and in synergy within the team :

  • Molecular mechanisms involved in OPMD and in muscle ageing
  • Cell-to-cell communication during muscle regeneration, muscle ageing and fibrosis
  • Development of therapeutic strategies

 

International associated laboratory (LIA) between France and Brazil:

Another aspect specific to our team is the development of international collaborations. In addition to numerous collaborations established over many years, we have set up an international associated laboratory between INSERM and Sorbonne University on the French side, and FIOCRUZ and the Federal University of Rio-de-Janeiro for the brazilian side. This LIA aims at synergize expertises on skeletal muscle and neuromuscular diseases from the French team and on inflammation from the Brazilian team. This LIA has been renew already once, and has produced 14 common publications, a common patent, long-term exchanges of 3 post-docs, 5 common PhD and many short term exchanges, including invited professors in both countries. A common teaching project is being set up (master and/or PhD), which will focus on innovative biotherapies for skeletal muscle.

Capucine Trollet et Vincent Mouly

Capucine Trollet et Vincent Mouly

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216 documents

  • Eugénie Ansseau, Dalila Laoudj-Chenivesse, Aline Marcowycz, Alexandra Tassin, Céline Vanderplanck, et al.. DUX4c Is Up-Regulated in FSHD. It Induces the MYF5 Protein and Human Myoblast Proliferation. PLoS ONE, 2009, 4 (10), pp.e7482. ⟨10.1371/journal.pone.0007482⟩. ⟨hal-03821134⟩
  • Simona Ozden, Marianne Lucas-Hourani, Pierre-Emmanuel Ceccaldi, Ajoy Basak, Menogh Valentine, et al.. Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein.. Journal of Biological Chemistry, 2008, 283 (32), pp.21899-908. ⟨10.1074/jbc.M802444200⟩. ⟨pasteur-00330695⟩
  • Anne Bigot, Virginie Jacquemin, Florence Debacq-Chainiaux, Gillian Butler-Browne, Olivier Toussaint, et al.. Replicative aging down-regulates the myogenic regulatory factors in human myoblasts. Biology of the Cell, 2008, 100 (3), pp.189-199. ⟨10.1042/BC20070085⟩. ⟨hal-03833741⟩
  • I. Riederer, E. Negroni, Anne Bigot, M. Bencze, J. Di Santo, et al.. Heat Shock Treatment Increases Engraftment of Transplanted Human Myoblasts Into Immunodeficient Mice. Transplantation Proceedings, 2008, 40 (2), pp.624-630. ⟨10.1016/j.transproceed.2008.01.026⟩. ⟨hal-03833753⟩
  • Florence Gonnet, Belaid Bouazza, Gael Armel Millot, Simin Ziaie, Luis Garcia, et al.. Proteome analysis of differentiating human myoblasts by dialysis assisted two dimensional gel electrophoresis (DAGE). Proteomics, 2008, 8 (2), pp.264-278. ⟨10.1002/pmic.200700261⟩. ⟨hal-00271318⟩
  • Valérie Allamand, Laure Bidou, Masayuki Arakawa, Célia Floquet, Masataka Shiozuka, et al.. Drug-induced readthrough of premature stop codons leads to the stabilization of laminin alpha2 chain mRNA in CMD myotubes.. The Journal of Gene Medicine, 2007, epub ahead of print. ⟨10.1002/jgm.1140⟩. ⟨hal-00198869⟩
  • Chun-Hong Zhu, Vincent Mouly, Racquel N. Cooper, Kamel Mamchaoui, Anne Bigot, et al.. Cellular senescence in human myoblasts is overcome by human telomerase reverse transcriptase and cyclin-dependent kinase 4: consequences in aging muscle and therapeutic strategies for muscular dystrophies. Aging Cell, 2007, 6 (4), pp.515-523. ⟨10.1111/j.1474-9726.2007.00306.x⟩. ⟨hal-03833731⟩
  • Simona Ozden, Michel Huerre, Jean-Pierre Riviere, Lark L Coffey, Philippe V Afonso, et al.. Human muscle satellite cells as targets of Chikungunya virus infection.. PLoS ONE, 2007, 2 (6), pp.e527. ⟨10.1371/journal.pone.0000527⟩. ⟨pasteur-00292848⟩
  • Capucine Trollet, Bloquel Carole, Scherman Daniel, Bigey Pascal. Electrotransfer into skeletal for protein expression. CURR. GENE THER., 2006, 6 (5), pp.561-578. ⟨inserm-00162511⟩
  • Carole Bloquel, Capucine Trollet, Elodie Pradines, Johanne Seguin, Daniel Scherman, et al.. Optical imaging of luminescence for in vivo quantification of gene electrotransfer in mouse muscle and knee.. BMC Biotechnology, 2006, 6, pp.16. ⟨10.1186/1472-6750-6-16⟩. ⟨inserm-00081253⟩
AFM Telethon : innover pour guérir
Assistance Publique Hôpitaux de Paris
FRM - Fondation Recherche Médicale
ERA-Net for Research Programmes on Rare Diseases
Coordinating research in the area of nutrition,  diet, health and physical activity
Fondation de l'avenir - Accélérateur de progrès médical
Université Sorbonne Paris Nord
Fondation Maladies Rares - Ensemble, trouvons des traitements !

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