Alain Sureau
Research scientist
Titles and positions
- Research Scientist (INSERM)
- PhD in Cellular and Molecular Biology, University of PARIS (Sorbonne University)
Expertises
- Cellular and molecular biology
- RNA
- mRNA processing
- Alternative splicing
- Myotonic Dystrophy Type 1
Presentation
Research Scientist (INSERM) in the group of D. Furling I am interested in the development of a new murine model for Myotonic Dystrophy Type 1 and in the characterization of the mechanisms that link the MBNL1 depletion and splicing changes to the increased risk of Venous Thromboembolism (VTE) in DM1 patients
Main publications
- Arandel, L, Matloka, M, Klein, AF, Rau, F, Sureau, A, Ney, M et al.. Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats. Nat Biomed Eng. 2022;6 (2):207-220. doi: 10.1038/s41551-021-00838-2. PubMed PMID:35145256 .
- Bauché, S, Sureau, A, Sternberg, D, Rendu, J, Buon, C, Messéant, J et al.. New recessive mutations in SYT2 causing severe presynaptic congenital myasthenic syndromes. Neurol Genet. 2020;6 (6):e534. doi: 10.1212/NXG.0000000000000534. PubMed PMID:33659639 PubMed Central PMC7803339.
- Hubé, F, Ulveling, D, Sureau, A, Forveille, S, Francastel, C. Short intron-derived ncRNAs. Nucleic Acids Res. 2017;45 (8):4768-4781. doi: 10.1093/nar/gkw1341. PubMed PMID:28053119 PubMed Central PMC5416886.
- Laurent, FX, Sureau, A, Klein, AF, Trouslard, F, Gasnier, E, Furling, D et al.. New function for the RNA helicase p68/DDX5 as a modifier of MBNL1 activity on expanded CUG repeats. Nucleic Acids Res. 2012;40 (7):3159-71. doi: 10.1093/nar/gkr1228. PubMed PMID:22156369 PubMed Central PMC3326330.
- Sureau, A, Saulière, J, Expert-Bezançon, A, Marie, J. CELF and PTB proteins modulate the inclusion of the β-tropomyosin exon 6B during myogenic differentiation. Exp Cell Res. 2011;317 (1):94-106. doi: 10.1016/j.yexcr.2010.09.010. PubMed PMID:20875406 .
- Saulière, J, Sureau, A, Expert-Bezançon, A, Marie, J. The polypyrimidine tract binding protein (PTB) represses splicing of exon 6B from the beta-tropomyosin pre-mRNA by directly interfering with the binding of the U2AF65 subunit. Mol Cell Biol. 2006;26 (23):8755-69. doi: 10.1128/MCB.00893-06. PubMed PMID:16982681 PubMed Central PMC1636812.
- Expert-Bezançon, A, Sureau, A, Durosay, P, Salesse, R, Groeneveld, H, Lecaer, JP et al.. hnRNP A1 and the SR proteins ASF/SF2 and SC35 have antagonistic functions in splicing of beta-tropomyosin exon 6B. J Biol Chem. 2004;279 (37):38249-59. doi: 10.1074/jbc.M405377200. PubMed PMID:15208309 .
- Sureau, A, Gattoni, R, Dooghe, Y, Stévenin, J, Soret, J. SC35 autoregulates its expression by promoting splicing events that destabilize its mRNAs. EMBO J. 2001;20 (7):1785-96. doi: 10.1093/emboj/20.7.1785. PubMed PMID:11285241 PubMed Central PMC145484.
- Sureau, A, Soret, J, Guyon, C, Gaillard, C, Dumon, S, Keller, M et al.. Characterization of multiple alternative RNAs resulting from antisense transcription of the PR264/SC35 splicing factor gene. Nucleic Acids Res. 1997;25 (22):4513-22. doi: 10.1093/nar/25.22.4513. PubMed PMID:9358160 PubMed Central PMC147067.