All the teams

Noyau MEC


Genetics and pathophysiology of neuromuscular disorders linked to the extracellular matrix and to the nucleus

The team’s research themes focus on 2 groups of Neuromuscular Diseases (MNM): myopathies due to abnormalities in the Myomatrix and in the Myonucleus due to mutations in the LMNA gene encoding type A Lamin or genes encoding components related to the nuclear membrane.


Muscle cell organization and therapy of dominant centronuclear myopathy

Strengthening our knowledge on the fundamental aspects of muscle biology is a challenge to increase our understanding of the diseases affecting this tissue and to identify new targets for therapeutic intervention. This is the objective of our team through the study of mechano-transduction, cytoskeleton-nuclear envelope connections, the machinery of endocytosis and the fate of adeno-associated viral vectors in healthy and pathological muscle. Our ambition is also to better characterize the group of congenital myopathies and to provide a therapeutic solution to patients with the dominant form of centronuclear myopathy.


Cellular and molecular orchestration in muscle regeneration, during ageing and in pathologies

The team is interested in the molecular and cellular actors involved in human muscle regeneration, muscle aging and muscular dystrophies, particularly oculoparyngeal muscular dystrophy (OPMD) and Duchenne Muscular Dystrophy (DMD).

Noyaux de cellules musculaires de patient DM1 dans lesquels des agrégats d’ARN mutés sont mis en évidence.


Repeat Expansions & Myotonic Dystrophy (REDs)

The translational research theme of the team focuses on the pathophysiology of myotonic dystrophy (DM1) or Steinert’s disease caused by an unstable expansion of CTG repeats, as well as the development and evaluation of therapies for this neuromuscular disease.

Fibres DHPR


Gene therapy for DMD and pathophysiology of skeletal muscle group

Dystrophinopathies are pathologies caused by abnormalities in the DMD gene that encodes a protein called dystrophin. This protein is absent in Duchenne Muscular Dystrophy (DMD) while it is present but qualitatively and/or quantitatively altered in Becker Muscular Dystrophy (BMD).


Biotherapies for motor neuron disorders (ALS & SMA)

The main objective of our team is to identify effective strategies for gene transfer in the central nervous system (CNS) and thus develop new therapies to treat motor neuron diseases. Spinal amyotrophy (SMA) and amyotrophic lateral sclerosis (ALS) are two such pathologies that still have no cure

Thymus AChR-MG


Myasthenia Gravis: etiology, pathophysiological & therapeutic approaches

Autoimmune myasthenia gravis is a complex disease related to the production of autoantibodies targeting the neuromuscular junction. The team is interested in the etiological and pathophysiological mechanisms involved in myasthenia by studying in particular the dysfunctions of the immune system and the involvement of the thymus.

Infiltrat inflammatoire dans un muscle de patient de myosite à inclusion


Inflammatory Myopathies & Innovative Therapies

The team is heavily involved in translational medicine studies focused on muscle immunology (from primary inflammatory myopathies (myositis) to immune reactions caused by cancer immunotherapies.


Signal pathways and striated muscles

Striated muscles account for about 40% of the total body weight, contain 50-75% of the body’s total protein, and contribute significantly to multiple body functions. There are two types of striated muscles : skeletal muscles and heart muscle.

JNM development


Neuromuscular Connectivity in health and diseases

Our team is interested in the cellular and molecular mechanisms underlying the assembly and maintenance of the neuromuscular synapse in physiological and pathological conditions. The neuromuscular junction (JNM) is the contact area that is established between the motor neurons and the muscle fibers they Innervate.

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