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Geneviève Gourdon

Research Director, co-team leader

Geneviève Gourdon
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Main publications

  1. Ait Benichou, S, Jauvin, D, De Serres-Bérard, T, Pierre, M, Ling, KK, Bennett, CF et al.. Antisense oligonucleotides as a potential treatment for brain deficits observed in myotonic dystrophy type 1. Gene Ther. 2022;29 (12):698-709. doi: 10.1038/s41434-022-00316-7. PubMed PMID:35075265 PubMed Central PMC9750879.
  2. Potier, B, Lallemant, L, Parrot, S, Huguet-Lachon, A, Gourdon, G, Dutar, P et al.. DM1 Transgenic Mice Exhibit Abnormal Neurotransmitter Homeostasis and Synaptic Plasticity in Association with RNA Foci and Mis-Splicing in the Hippocampus. Int J Mol Sci. 2022;23 (2):. doi: 10.3390/ijms23020592. PubMed PMID:35054778 PubMed Central PMC8775431.
  3. Cardinali, B, Provenzano, C, Izzo, M, Voellenkle, C, Battistini, J, Strimpakos, G et al.. Time-controlled and muscle-specific CRISPR/Cas9-mediated deletion of CTG-repeat expansion in the DMPK gene. Mol Ther Nucleic Acids. 2022;27 :184-199. doi: 10.1016/j.omtn.2021.11.024. PubMed PMID:34976437 PubMed Central PMC8693309.
  4. Parrot, S, Corscadden, A, Lallemant, L, Benyamine, H, Comte, JC, Huguet-Lachon, A et al.. Defects in Mouse Cortical Glutamate Uptake Can Be Unveiled In Vivo by a Two-in-One Quantitative Microdialysis. ACS Chem Neurosci. 2022;13 (1):134-142. doi: 10.1021/acschemneuro.1c00634. PubMed PMID:34923816 .
  5. González-Barriga, A, Lallemant, L, Dincã, DM, Braz, SO, Polvèche, H, Magneron, P et al.. Integrative Cell Type-Specific Multi-Omics Approaches Reveal Impaired Programs of Glial Cell Differentiation in Mouse Culture Models of DM1. Front Cell Neurosci. 2021;15 :662035. doi: 10.3389/fncel.2021.662035. PubMed PMID:34025359 PubMed Central PMC8136287.
  6. Wansink, DG, Gourdon, G, van Engelen, BGM, Schoser, B, DM workshop study group. 248th ENMC International Workshop: Myotonic dystrophies: Molecular approaches for clinical purposes, framing a European molecular research network, Hoofddorp, the Netherlands, 11-13 October 2019. Neuromuscul Disord. 2020;30 (6):521-531. doi: 10.1016/j.nmd.2020.03.011. PubMed PMID:32417002 .
  7. Lo Scrudato, M, Poulard, K, Sourd, C, Tomé, S, Klein, AF, Corre, G et al.. Genome Editing of Expanded CTG Repeats within the Human DMPK Gene Reduces Nuclear RNA Foci in the Muscle of DM1 Mice. Mol Ther. 2019;27 (8):1372-1388. doi: 10.1016/j.ymthe.2019.05.021. PubMed PMID:31253581 PubMed Central PMC6697452.
  8. Sicot, G, Servais, L, Dinca, DM, Leroy, A, Prigogine, C, Medja, F et al.. Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy. Cell Rep. 2017;19 (13):2718-2729. doi: 10.1016/j.celrep.2017.06.006. PubMed PMID:28658620 PubMed Central PMC8496958.
  9. Hernández-Hernández, O, Guiraud-Dogan, C, Sicot, G, Huguet, A, Luilier, S, Steidl, E et al.. Myotonic dystrophy CTG expansion affects synaptic vesicle proteins, neurotransmission and mouse behaviour. Brain. 2013;136 (Pt 3):957-70. doi: 10.1093/brain/aws367. PubMed PMID:23404338 PubMed Central PMC3580270.
  10. Huguet, A, Medja, F, Nicole, A, Vignaud, A, Guiraud-Dogan, C, Ferry, A et al.. Molecular, physiological, and motor performance defects in DMSXL mice carrying >1,000 CTG repeats from the human DM1 locus. PLoS Genet. 2012;8 (11):e1003043. doi: 10.1371/journal.pgen.1003043. PubMed PMID:23209425 PubMed Central PMC3510028.
  11. Tomé, S, Panigrahi, GB, López Castel, A, Foiry, L, Melton, DW, Gourdon, G et al.. Maternal germline-specific effect of DNA ligase I on CTG/CAG instability. Hum Mol Genet. 2011;20 (11):2131-43. doi: 10.1093/hmg/ddr099. PubMed PMID:21378394 .
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