Cellular and molecular orchestration in muscle regeneration, during ageing and in pathologies.
The team focuses on molecular and cellular actors involved in human in skeletal muscle regeneration, during ageing and in muscle dystrophies, particularly oculo-pharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). Our approaches aim at better understandng RNA metabolism, muscle regeneration, muscle stem cells and fibrosis, in order to develop therapeutic strategies.The team has developed a solid expertise on cellular models (incuding through the MyoLine platform for immortalization taht we have set up) and on xenotransplantation using several immunodeficient mouse models and different types of grafts.
Research projects currently developed in parralel and in synergy within the team :
- Molecular mechanisms involved in OPMD and in muscle ageing
- Cell-to-cell communication during muscle regeneration, muscle ageing and fibrosis
- Development of therapeutic strategies
International associated laboratory (LIA) between France and Brazil:
Another aspect specific to our team is the development of international collaborations. In addition to numerous collaborations established over many years, we have set up an international associated laboratory between INSERM and Sorbonne University on the French side, and FIOCRUZ and the Federal University of Rio-de-Janeiro for the brazilian side. This LIA aims at synergize expertises on skeletal muscle and neuromuscular diseases from the French team and on inflammation from the Brazilian team. This LIA has been renew already once, and has produced 14 common publications, a common patent, long-term exchanges of 3 post-docs, 5 common PhD and many short term exchanges, including invited professors in both countries. A common teaching project is being set up (master and/or PhD), which will focus on innovative biotherapies for skeletal muscle.
| Name | Position | ORCID |
|---|
- Capucine Trollet. Transfert de gène in vivo:
étude, régulation et application de l'électrotransfert. Biochimie [q-bio.BM]. Chimie ParisTech, 2005. Français. ⟨NNT : ⟩. ⟨tel-00011410⟩ - V. Mouly, A. Aamiri, Anne Bigot, R. Cooper, S. Di Donna, et al.. The mitotic clock in skeletal muscle regeneration, disease and cell mediated gene therapy. Acta Physiologica Scandinavica, 2005, 184 (1), pp.3-15. ⟨10.1111/j.1365-201X.2005.01417.x⟩. ⟨hal-03833720⟩
- V Jacquemin, D Furling, Anne Bigot, G.S Butler-Browne, V Mouly. IGF-1 induces human myotube hypertrophy by increasing cell recruitment. Experimental Cell Research, 2004, 299 (1), pp.148-158. ⟨10.1016/j.yexcr.2004.05.023⟩. ⟨hal-03833701⟩
- Ana Buj-Bello, Furling D, Helene Tronchere, Jocelyn Laporte, Thierry Lerouge, et al.. Muscle-specific alternative splicing of myotubularin-related 1 gene is impaired in DM1 muscle cells. Human Molecular Genetics, 2002, 11 (19), pp.2297-2307. ⟨10.1093/hmg/11.19.2297⟩. ⟨hal-04481805⟩
- V. Mouly, M. Lemonnier, D. Libri, Fiszman M.Y.. TRANSFORMATION ET CLONAGE DES MYOBLASTES AU COURS DU DEVELOPPEMENT CHEZ LES OISEAUX. Reproduction Nutrition Development, 1989, 29 (Suppl), pp.32-32. ⟨hal-00899158⟩
- V. Mouly, M. Y. Fiszman. Plusieurs classes de myoblastes participent à la formation des muscles du squelette chez les oiseaux. Reproduction Nutrition Développement, 1988, 28 (3B), pp.687-692. ⟨hal-00898863⟩
Powered by HAL 
