Zoom link => https://zoom.us/j/99899672100
Cellular and Molecular Drivers of Fibrosis in RNA Toxicity
Mani S. Mahadevan
Professor, University of Virginia
Dr. M.S Mahadevan worked in the area of RNA toxicity and disease for the past 30 years, with a focus on myotonic dystrophy (DM1). He was one of the discoverers of the DM1 mutation, sequenced the DMPK gene, and subsequently studied DM pathogenesis and helped establish the concept of RNA toxicity in disease with an emphasis on muscle and cardiac effects. Recently, he used an inducible mouse models of RNA toxicity to demonstrate a dystrophic phenotype including fatty infiltration and fibrosis that is amenable to antisense oligonucleotide based therapeutics.
