Cellular and molecular orchestration in muscle regeneration, during ageing and in pathologies.
The team focuses on molecular and cellular actors involved in human in skeletal muscle regeneration, during ageing and in muscle dystrophies, particularly oculo-pharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). Our approaches aim at better understandng RNA metabolism, muscle regeneration, muscle stem cells and fibrosis, in order to develop therapeutic strategies.The team has developed a solid expertise on cellular models (incuding through the MyoLine platform for immortalization taht we have set up) and on xenotransplantation using several immunodeficient mouse models and different types of grafts.
Research projects currently developed in parralel and in synergy within the team :
- Molecular mechanisms involved in OPMD and in muscle ageing
- Cell-to-cell communication during muscle regeneration, muscle ageing and fibrosis
- Development of therapeutic strategies
International associated laboratory (LIA) between France and Brazil:
Another aspect specific to our team is the development of international collaborations. In addition to numerous collaborations established over many years, we have set up an international associated laboratory between INSERM and Sorbonne University on the French side, and FIOCRUZ and the Federal University of Rio-de-Janeiro for the brazilian side. This LIA aims at synergize expertises on skeletal muscle and neuromuscular diseases from the French team and on inflammation from the Brazilian team. This LIA has been renew already once, and has produced 14 common publications, a common patent, long-term exchanges of 3 post-docs, 5 common PhD and many short term exchanges, including invited professors in both countries. A common teaching project is being set up (master and/or PhD), which will focus on innovative biotherapies for skeletal muscle.
| Name | Position | ORCID |
|---|
- Aziz Guellich, Elisa Negroni, Valérie Decostre, Alexandre Demoule, Catherine Coirault. Altered cross-bridge properties in skeletal muscle dystrophies. Frontiers in Physiology, 2014, 5, ⟨10.3389/fphys.2014.00393⟩. ⟨inserm-02426461⟩
- Capucine Trollet, Aymeric Chartier, Pierre Klein, Nicolas Barbezier, Teresa Gidaro, et al.. Mitochondrial dysfunction reveals defective poly(A) tail regulation of specific mRNAs as a primary defect in oculopharyngeal muscular dystrophy. 19. International Congress of the World Muscle Society, Oct 2014, Berlin, Germany. pp.793-794. ⟨hal-02740677⟩
- Lourenco Sofia, Trollet Capucine, S. Butler-Browne Gillian, Friguet Bertrand, Petropoulos Isabelle. Role of Oxidized Protein Repair in Human Skeletal Muscle. Free Radical Biology and Medicine, 2014, 75 (1), pp.S39. ⟨10.1016/j.freeradbiomed.2014.10.787⟩. ⟨hal-01543973⟩
- Fabien Chevalier, Mélanie Lavergne, Elisa Negroni, Ségolène Ferratge, Gilles Carpentier, et al.. Glycosaminoglycan mimetic improves enrichment and cell functions of human endothelial progenitor cell colonies. Stem Cell Research, 2014, 12 (3), pp.703-715. ⟨10.1016/j.scr.2014.03.001⟩. ⟨hal-03097738⟩
- Claudia Langhans, Steffen Weber-Carstens, Franziska Schmidt, Jida Hamati, Melanie Kny, et al.. Inflammation-Induced Acute Phase Response in Skeletal Muscle and Critical Illness Myopathy. PLoS ONE, 2014, 9 (3), pp.e92048. ⟨10.1371/journal.pone.0092048⟩. ⟨hal-01365918⟩
- Aziz Guellich, Elisa Negroni, Valérie Decostre, Alexandre Demoule, Catherine Coirault. Altered cross-bridge properties in skeletal muscle dystrophies. Frontiers in Physiology, 2014, 5, pp.393. ⟨10.3389/fphys.2014.00393⟩. ⟨hal-01324470⟩
- Sophie Périé, Capucine Trollet, Vincent Mouly, Valérie Vanneaux, Kamel Mamchaoui, et al.. Autologous Myoblast Transplantation for Oculopharyngeal Muscular Dystrophy: a Phase I/Iia Clinical Study. Molecular Therapy, 2014, 22 (1), pp.219-225. ⟨10.1038/mt.2013.155⟩. ⟨hal-03832804⟩
- Aurore Burgain, Alice Rochard, Capucine Trollet, Christelle Mazuet, Michel Popoff, et al.. DNA electroporation in rabbits as a method for generation of high-titer neutralizing antisera. Human Vaccines & Immunotherapeutics, 2013, 9 (10), pp.2147 - 2156. ⟨10.4161/hv.25192⟩. ⟨pasteur-01766305⟩
- M Ferreboeuf, V. Mariot, B. Bessières, A Vasiljevic, Tania Attié-Bitach, et al.. DUX 4 and DUX4 downstream target genes are expressed in fetal FSHD muscles. 18th International Congress of The World Muscle Society, Oct 2013, Pacific Grove, CA, United States. pp.823, ⟨10.1016/j.nmd.2013.06.640⟩. ⟨hal-01907613⟩
- Maxime Ferreboeuf, Virginie Mariot, Bettina Bessières, Alexandre Vasiljevic, Tania Attié-Bitach, et al.. DUX4 and DUX4 downstream target genes are expressed in fetal FSHD muscles.. Human Molecular Genetics, 2013, 23 (1), epub ahead of print. ⟨10.1093/hmg/ddt409⟩. ⟨hal-00868855⟩
Powered by HAL 
