Cellular and molecular orchestration in muscle regeneration, during ageing and in pathologies.
The team focuses on molecular and cellular actors involved in human in skeletal muscle regeneration, during ageing and in muscle dystrophies, particularly oculo-pharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). Our approaches aim at better understandng RNA metabolism, muscle regeneration, muscle stem cells and fibrosis, in order to develop therapeutic strategies.The team has developed a solid expertise on cellular models (incuding through the MyoLine platform for immortalization taht we have set up) and on xenotransplantation using several immunodeficient mouse models and different types of grafts.
Research projects currently developed in parralel and in synergy within the team :
- Molecular mechanisms involved in OPMD and in muscle ageing
- Cell-to-cell communication during muscle regeneration, muscle ageing and fibrosis
- Development of therapeutic strategies
International associated laboratory (LIA) between France and Brazil:
Another aspect specific to our team is the development of international collaborations. In addition to numerous collaborations established over many years, we have set up an international associated laboratory between INSERM and Sorbonne University on the French side, and FIOCRUZ and the Federal University of Rio-de-Janeiro for the brazilian side. This LIA aims at synergize expertises on skeletal muscle and neuromuscular diseases from the French team and on inflammation from the Brazilian team. This LIA has been renew already once, and has produced 14 common publications, a common patent, long-term exchanges of 3 post-docs, 5 common PhD and many short term exchanges, including invited professors in both countries. A common teaching project is being set up (master and/or PhD), which will focus on innovative biotherapies for skeletal muscle.
| Name | Position | ORCID |
|---|
- Laura Muraine, Mona Bensalah, Jean Lacau St Guily, Aurélien Corneau, Gillian S. Butler-Browne, et al.. Muscle fibrosis: a vicious circle between human fibroadipogenic progenitors and muscle fibers. 18èmes Journées de la Société Française de Myologie, Nov 2021, Saint Etienne, France. ⟨hal-04011352⟩
- Alexis Boulinguiez, Capucine Trollet. Reducing ER stress to resolve aggresome accumulation in oculopharyngeal muscular dystrophy. Frontiers in Myogenesis Conference, Nov 2021, Herradura, Costa Rica. ⟨hal-04010913⟩
- Xavier Suárez‐calvet, Esther Fernández‐simón, Patricia Piñol‐jurado, Jorge Alonso‐pérez, Ana Carrasco‐rozas, et al.. Isolation of human fibroadipogenic progenitors and satellite cells from frozen muscle biopsies. FASEB Journal, 2021, 35 (9), ⟨10.1096/fj.202100588r⟩. ⟨hal-03350045⟩
- Marco Narici, Jamie Mcphee, Maria Conte, Martino V Franchi, Kyle Mitchell, et al.. Age‐related alterations in muscle architecture are a signature of sarcopenia: the ultrasound sarcopenia index. Journal of Cachexia, Sarcopenia and Muscle, 2021, ⟨10.1002/jcsm.12720⟩. ⟨hal-03256174⟩
- Vanessa Strings-Ufombah, Alberto Malerba, Shih-Chu Kao, Sonal Harbaran, Fanny Roth, et al.. BB-301: a silence and replace AAV-based vector for the treatment of oculopharyngeal muscular dystrophy. Molecular Therapy - Nucleic Acids, 2021, 24, pp.67 - 78. ⟨10.1016/j.omtn.2021.02.017⟩. ⟨hal-03176223⟩
- Capucine Trollet, Arthur J Cheng, Lykke Sylow, Miguel L Batista, Nicolas J Pillon. Editorial: Skeletal Muscle Immunometabolism. Frontiers in Physiology, 2021, 12, ⟨10.3389/fphys.2021.683088⟩. ⟨hal-03229646⟩
- Jasdeep Saini, Alessandro Faroni, Adam J Reid, Vincent Mouly, Gillian Butler-Browne, et al.. Cross‐talk between motor neurons and myotubes via endogenously secreted neural and muscular growth factors. Physiological Reports, 2021, 9 (8), pp.e14791. ⟨10.14814/phy2.14791⟩. ⟨hal-03215215⟩
- Aline Bamia, Maha Sinane, Rima Naït-Saïdi, Jamila Dhiab, Marc Keruzoré, et al.. Anti-prion Drugs Targeting the Protein Folding Activity of the Ribosome Reduce PABPN1 Aggregation. Neurotherapeutics, 2021, 18 (2), pp.1137-1150. ⟨10.1007/s13311-020-00992-6⟩. ⟨hal-03158577⟩
- Capucine Trollet, Gillian S. Butler-Browne. Therapeutic approaches for oculopharyngeal muscular dystrophy: where are we now?. Padua Days of Muscle and Mobility Medicine, 2021, Virtual conference, France. ⟨hal-04011383⟩
- Laura Muraine, Ludovic Gaut, Mona Bensalah, Gillian S. Butler-Browne, Vincent Mouly, et al.. Intercellular communication in fibrotic and aged human skeletal muscle. Workshop « Inflamaging and Regeneration: Pain or Partnership? », 2021, Virtual conference, France. ⟨hal-04011377⟩
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