Cellular and molecular orchestration in muscle regeneration, during ageing and in pathologies.
The team focuses on molecular and cellular actors involved in human in skeletal muscle regeneration, during ageing and in muscle dystrophies, particularly oculo-pharyngeal muscular dystrophy (OPMD) and Duchenne muscular dystrophy (DMD). Our approaches aim at better understandng RNA metabolism, muscle regeneration, muscle stem cells and fibrosis, in order to develop therapeutic strategies.The team has developed a solid expertise on cellular models (incuding through the MyoLine platform for immortalization taht we have set up) and on xenotransplantation using several immunodeficient mouse models and different types of grafts.
Research projects currently developed in parralel and in synergy within the team :
- Molecular mechanisms involved in OPMD and in muscle ageing
- Cell-to-cell communication during muscle regeneration, muscle ageing and fibrosis
- Development of therapeutic strategies
International associated laboratory (LIA) between France and Brazil:
Another aspect specific to our team is the development of international collaborations. In addition to numerous collaborations established over many years, we have set up an international associated laboratory between INSERM and Sorbonne University on the French side, and FIOCRUZ and the Federal University of Rio-de-Janeiro for the brazilian side. This LIA aims at synergize expertises on skeletal muscle and neuromuscular diseases from the French team and on inflammation from the Brazilian team. This LIA has been renew already once, and has produced 14 common publications, a common patent, long-term exchanges of 3 post-docs, 5 common PhD and many short term exchanges, including invited professors in both countries. A common teaching project is being set up (master and/or PhD), which will focus on innovative biotherapies for skeletal muscle.
| Name | Position | ORCID |
|---|
- Adriana C. Bonomo, Fernanda Pinto-Mariz, Ingo Riederer, Claudia F. Benjamim, Gillian Butler-Browne, et al.. Crosstalk Between Innate and T Cell Adaptive Immunity With(in) the Muscle. Frontiers in Physiology, 2020, 11, pp.573347. ⟨10.3389/fphys.2020.573347⟩. ⟨hal-02978746⟩
- Laura Le Gall, Zamalou Gisele Ouandaogo, Ekene Anakor, Owen Connolly, Gillian Butler Browne, et al.. Optimized method for extraction of exosomes from human primary muscle cells. Skeletal Muscle, 2020, 10 (1), ⟨10.1186/s13395-020-00238-1⟩. ⟨hal-03276085⟩
- Maud Wurmser, Nathalie Chaverot, Rouba Madani, Hiroshi Sakai, Elisa Negroni, et al.. SIX1 and SIX4 homeoproteins regulate PAX7+ progenitor cell properties during fetal epaxial myogenesis. Development (Cambridge, England), 2020, pp.dev.185975. ⟨10.1242/dev.185975⟩. ⟨hal-02905565⟩
- Claudia Filippone, Vincent Legros, Patricia Jeannin, Valérie Choumet, Gillian Butler-Browne, et al.. Arboviruses and Muscle Disorders: From Disease to Cell Biology. Viruses, 2020, 12 (6), pp.E616. ⟨10.3390/v12060616⟩. ⟨hal-02905586⟩
- Daniel J Owens, Martina Fischer, Saline Jabre, Sophie Moog, Kamel Mamchaoui, et al.. Lamin Mutations Cause Increased YAP Nuclear Entry in Muscle Stem Cells. Cells, 2020, 9 (4), pp.E816. ⟨10.3390/cells9040816⟩. ⟨inserm-02538651⟩
- Cara A Timpani, Craig A Goodman, Christos G Stathis, Jason D White, Kamel Mamchaoui, et al.. Adenylosuccinic acid therapy ameliorates murine Duchenne Muscular Dystrophy. Scientific Reports, 2020, 10 (1), pp.1125. ⟨10.1038/s41598-020-57610-w⟩. ⟨inserm-02486207⟩
- Stéphane M Camus, Marine Camus, Carmen Figueras-Novoa, Gaelle Boncompain, L. Amanda Sadacca, et al.. CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis. Journal of Cell Biology, 2020, 219 (1), ⟨10.1083/jcb.201812135⟩. ⟨hal-02555498⟩
- Ximena Baez-Matus, Cindel Figueroa-Cares, Arlek Gonzalez-Jamett, Hugo Almarza-Salazar, Christian Arriagada, et al.. Defects in G-Actin Incorporation into Filaments in Myoblasts Derived from Dysferlinopathy Patients Are Restored by Dysferlin C2 Domains. International Journal of Molecular Sciences, 2020, 21 (1), pp.37. ⟨10.3390/ijms21010037⟩. ⟨hal-02512306⟩
- Vincent Legros, Patricia Jeannin, Julien Burlaud-Gaillard, Thibault Chaze, Quentin Giai Gianetto, et al.. Differentiation-dependent susceptibility of human muscle cells to Zika virus infection. PLoS Neglected Tropical Diseases, 2020, 14 (8), pp.e0008282. ⟨10.1371/journal.pntd.0008282⟩. ⟨hal-03184236⟩
- Laura Muraine, Mona Bensalah, Jamila Dhiab, Gonzalo Cordova, Ludovic Arandel, et al.. Transduction Efficiency of Adeno-Associated Virus Serotypes After Local Injection in Mouse and Human Skeletal Muscle. Human Gene Therapy, In press, ⟨10.1089/hum.2019.173⟩. ⟨hal-02472542⟩
Powered by HAL 
