Monday Muscle Seminar M&Ms: Mani S. Mahadevan

Zoom link => https://zoom.us/j/99899672100

Cellular and Molecular Drivers of Fibrosis in RNA Toxicity

Mani S. Mahadevan

Professor, University of Virginia

Dr. M.S Mahadevan worked in the area of RNA toxicity and disease for the past 30 years, with a focus on myotonic dystrophy (DM1). He was one of the discoverers of the DM1 mutation, sequenced the DMPK gene, and subsequently studied DM pathogenesis and helped establish the concept of RNA toxicity in disease with an emphasis on muscle and cardiac effects.  Recently, he used an inducible mouse models of RNA toxicity to demonstrate a dystrophic phenotype including fatty infiltration and fibrosis that is amenable to antisense oligonucleotide based therapeutics.  

Date de début : 18 novembre 2024

Date de fin : 18 novembre 2024

Heure : 12:00 - 13:00

Lieu: Visioconference

Monday Muscle Seminar - M&M's

M.S Mahadevan