Séminaires et conférences

Cristiana Perrotta Biography

My scientific path started with the characterization of anabolic and catabolic circulating factors that associate with muscle wasting in several animal models of cancer cachexia, finding reduced IGF-1 and increased myostatin as common signs induced by tumor growth. My research provided the first evidence that tumor growth impairs the myogenic potential and that ERK inhibition rescues the myogenic capacity and partially prevents muscle depletion in tumor hosts. In parallel, I described the specific effects of tumor growth on muscle mitochondria and the ability of training exercise to revert such alterations in order to move the scientific interest from muscle mass to muscle quality, function, and metabolism. The current focus of my research has moved from a muscle centric perspective to a broad host metabolism approach, in order to understand cancer as a systemic host disease.

Johan Auwerx is using systems biology and genetics approaches to understand the communication between the mitochondria and the nucleus. His work is relevant for the areas of transcription, mitochondria, metabolism, and aging. His research spurred the development of new drugs, such as PPAR agonists, Urolithins, PARP and ACMSD inhibitors and other NAD⁺ boosters for the treatment of age-related metabolic, cardio-vascular and neuro-muscular diseases. Johan Auwerx was elected as a member of EMBO in 2003 and has received many international scientific prizes. He is the founder of several biotech companies.

More information on the Corces Lab

Michael Snyder Biosktech

PAMELA SHAW BIOSKETCH CV MARCH 2023

More information on Eric Wang laboratory

Eric T. Wang – Principal Investigator
Eric received his BA in Biochemistry at Harvard College and PhD from the Harvard-MIT Division of Health Sciences & Technology. Following receipt of an NIH Early Independence Award, he started his lab as a Koch Institute Fellow, and subsequently moved to the University of Florida as an Assistant Professor. His interests lie at the intersection of genomics and cell biology, with a focus on better understanding disease pathogenesis underlying repeat expansion diseases. A family connection led him to focus on myotonic dystrophy, a multi-systemic disease affecting muscle, heart, and brain. He has worked with the Myotonic Dystrophy Foundation, the Muscular Dystrophy Association, and Promise to Kate to raise awareness and funding for research. He co-founded Strength, Science and Stories of Inspiration to support the research of young investigators. He also interacts extensively with drug companies to develop meaningful treatment options for people living with severe neurological diseases.