Piera Smeriglio
Research scientist (CR Inserm)
Expertises
- Epigenetics
- Stem cells
- Tissue engineering
- Musculoskeletal pathophysiology
Présentation
Dr Smeriglio, a researcher at the Institut de Myologie in Paris, leads a diverse team of researchers dedicated to the study of motor neuron diseases. A specialist in the epigenetic regulation of these pathologies, she uses cutting-edge multi-omics technologies to identify new therapeutic targets. The Marie Skłodowska-Curie postdoctoral fellowship from the European Union (MSCA) received in 2020 enabled her to launch her research into the complex epigenetic factors influencing motor neuron diseases. This led her to head her team, which is currently accredited by the HCERES. Since 2022, as a full researcher at INSERM, she strives to translate scientific discoveries into clinical applications, fostering a close relationship between research and patient care. She also holds an HDR from the Sorbonne and is involved in numerous international projects, including the Sorbonne/Fiocruz international program (Brazil) and the Erdera European consortium on rare diseases.
Principales publications
- Smeriglio, P, Grandi, FC, Davala, S, Masarapu, V, Indelli, PF, Goodman, SB et al.. Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis. Sci Transl Med. 2020;12 (539):. doi: 10.1126/scitranslmed.aax2332. PubMed PMID:32295898 .
- Smeriglio, P, Lee, J, Bhutani, N. Soluble Collagen VI treatment enhances mesenchymal stem cells expansion for engineering cartilage. Bioeng Transl Med. 2017;2 (3):278-284. doi: 10.1002/btm2.10078. PubMed PMID:29313037 PubMed Central PMC5689496.
- Taylor, SE, Li, YH, Smeriglio, P, Rath, M, Wong, WH, Bhutani, N et al.. Stable 5-Hydroxymethylcytosine (5hmC) Acquisition Marks Gene Activation During Chondrogenic Differentiation. J Bone Miner Res. 2016;31 (3):524-34. doi: 10.1002/jbmr.2711. PubMed PMID:26363184 PubMed Central PMC4860191.