Personnel

My professional career began in 2003, after obtaining a 3rd year specialization and then a diploma from the EPHE, in the group of France Piétri-Rouxel in the department of infectious diseases at the Cochin Institute. Thereafter, the group joined Luis Garcia's team at Genethon, where we explored the role of the alpha 1S subunit of DHPR (key protein of the excitation-contraction coupling) in the maintenance of muscle mass. These studies have continued at the Centre of Research for Myology and the acquisition of several skills in molecular and cellular biology and biochemistry allowed me to obtain a Master 2 degree by validating the acquired experience (VAE). Then, in a perspective of clinical trials to treat Duchenne muscular dystrophy, I participated in 2 studies showing that the severity of the dystrophic phenotype correlated with the nitrosylation of RyR1 by the nNOS and iNOS proteins. My involvement in these projects, from conception to realization, allowed me to undertake again a VAE process to obtain a PhD that I validated in 2018. After the publication of our study that demonstrated the correlation between the expression of the β subunit of DHPR and the GDF5 protein with age-related muscle mass loss, I started a new project to study a potential beneficial effect of GDF5 in dystrophic muscle.