Frédérique Rau
Research scientist
Titres
Expertises
- Molecular biology
- RNA metabolism
- Myotonic dystrophy
Principales publications
- Hallegger, M, Chakrabarti, AM, Lee, FCY, Lee, BL, Amalietti, AG, Odeh, HM et al.. TDP-43 condensation properties specify its RNA-binding and regulatory repertoire. Cell. 2021;184 (18):4680-4696.e22. doi: 10.1016/j.cell.2021.07.018. PubMed PMID:34380047 PubMed Central PMC8445024.
- Matloka, M, Klein, AF, Rau, F, Furling, D. Cells of Matter-In Vitro Models for Myotonic Dystrophy. Front Neurol. 2018;9 :361. doi: 10.3389/fneur.2018.00361. PubMed PMID:29875732 PubMed Central PMC5974047.
- Peskett, TR, Rau, F, O'Driscoll, J, Patani, R, Lowe, AR, Saibil, HR et al.. A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation. Mol Cell. 2018;70 (4):588-601.e6. doi: 10.1016/j.molcel.2018.04.007. PubMed PMID:29754822 PubMed Central PMC5971205.
- Arandel, L, Polay Espinoza, M, Matloka, M, Bazinet, A, De Dea Diniz, D, Naouar, N et al.. Immortalized human myotonic dystrophy muscle cell lines to assess therapeutic compounds. Dis Model Mech. 2017;10 (4):487-497. doi: 10.1242/dmm.027367. PubMed PMID:28188264 PubMed Central PMC5399563.
- Roy, P, Rau, F, Ochala, J, Messéant, J, Fraysse, B, Lainé, J et al.. Dystrophin restoration therapy improves both the reduced excitability and the force drop induced by lengthening contractions in dystrophic mdx skeletal muscle. Skelet Muscle. 2016;6 :23. doi: 10.1186/s13395-016-0096-4. PubMed PMID:27441081 PubMed Central PMC4952281.
- Freyermuth, F, Rau, F, Kokunai, Y, Linke, T, Sellier, C, Nakamori, M et al.. Splicing misregulation of SCN5A contributes to cardiac-conduction delay and heart arrhythmia in myotonic dystrophy. Nat Commun. 2016;7 :11067. doi: 10.1038/ncomms11067. PubMed PMID:27063795 PubMed Central PMC4831019.
- Rau, F, Lainé, J, Ramanoudjame, L, Ferry, A, Arandel, L, Delalande, O et al.. Abnormal splicing switch of DMD's penultimate exon compromises muscle fibre maintenance in myotonic dystrophy. Nat Commun. 2015;6 :7205. doi: 10.1038/ncomms8205. PubMed PMID:26018658 PubMed Central PMC4458869.
- Rau, F, Freyermuth, F, Fugier, C, Villemin, JP, Fischer, MC, Jost, B et al.. Misregulation of miR-1 processing is associated with heart defects in myotonic dystrophy. Nat Struct Mol Biol. 2011;18 (7):840-5. doi: 10.1038/nsmb.2067. PubMed PMID:21685920 .
- Sellier, C, Rau, F, Liu, Y, Tassone, F, Hukema, RK, Gattoni, R et al.. Sam68 sequestration and partial loss of function are associated with splicing alterations in FXTAS patients. EMBO J. 2010;29 (7):1248-61. doi: 10.1038/emboj.2010.21. PubMed PMID:20186122 PubMed Central PMC2857464.
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